Serum apelin levels in polycystic ovary syndrome and its relationship with adiposity profile in females.

  • Sassi Kanwal Jinnah Medical and Dental College.
  • Ashba Allahwasaya Medical College, Aga Khan University.
  • Nargis Anjum Karachi Medical and Dental College and University of Karachi.
  • Syeda Sadia Fatima Aga Khan University.
Keywords: Apelin, Hirsutism, Irregular Menstrual, Obesity, PCOS


Objectives: The purpose of the current study was to compare the serum Apelin level in patients with and without polycystic ovarian syndrome to assess this as a diagnostic marker for PCOS. In a case-control study 60 polycystic ovarian syndrome patients diagnosed according to Rotterdam criteria and 20 healthy controls of reproductive age group were recruited. Study Design: Case Control study. Setting: Jinnah Postgraduate Medical Center in Collaboration with Aga Khan University, Karachi. Period: August 2017 and February 2019. Material & Methods: Blood samples were collected after 12 hours fasting and was used to test serum Apelin, insulin, cortisol and fasting blood glucose levels. Results: Seventy percent PCO subjects had irregular menstrual cycle and 68% suffered from hirsutism; while all PCO subjects had more than 10 antral follicle seen on ultrasound in either one or both ovaries in comparison of 15% controls (p<0.05). Higher Apelin and Testosterone levels in PCO group was reported when compared with controls (p<0.05) across all BMI categories. Apelin showed a positive correlation with number of ovarian cysts (r=0.429; p=0.000); irregular menstrual cyle (r=0.276;p=0.13); blood glucose level (r=0.270; p=0.015) and BMI (r=0.229; p=0.14). Apelin remained independently associated with the risk of PCOS (p=0.020) and elevated testosterone levels (p=0.030). Conclusion: Serum Apelin showed a strong association with irregular menstruation, hirsutism, ovarian cysts, testosterone and deranged blood glucose levels. Therefore, Apelin appears as a potential source for several risk factor in PCOS women of all BMI types.

Author Biographies

Sassi Kanwal, Jinnah Medical and Dental College.

MBBS, M.Phil

Lecturer Physiology

Ashba Allahwasaya, Medical College, Aga Khan University.

3rd Year MBBS Student


Nargis Anjum, Karachi Medical and Dental College and University of Karachi.

MBBS, M.Phil



Syeda Sadia Fatima, Aga Khan University.

MBBS, M.Phil, Ph.D, FHEA (UK)


Biological and Biomedical Sciences