Biochemical markers in the Wilson’s disease patients in adolescents presenting at tertiary care hospital.

Abstract

Objective: Estimating biochemical markers in Wilsons disease (WD) patients in adolescents group presenting at tertiary care hospital. Study Design: Cross Sectional study. Setting: Outpatients and Medical Wards, Isra University Hospital. Period: January 2024 to March 2025. Methods: One hundred diagnosed cases of WD were enrolled for estimating the biochemical markers of copper metabolism in adolescents. Cases were diagnosed and reconfirmed by a consultant physician. Blood sample were taken. Sonography was ordered. Biochemical parameters were estimated by Roche Cobas Chemistry Analyser and Atomic spectrophotometry. Variable were analyzed on SPSS 21.0 ver. P – value is taken at (USA) at 95% CI (P≤ 0.05). Results: Age was 17.31±7.97 years. Male - female ratio was 3:1. Icteric sclera was noted in 57 cases, hepatomegaly in 69 cases, splenomegaly in 71 cases, and KF rings noted in 21 cases. 24 hour urinary copper measured as 2913.5± 711.6 (409 – 3901) mg/dl serum ceruloplasmin measured as 17.01±54.87 mg/day. Conclusion: We observed low ceruloplasmin and high urinary copper in WD patients. Penicillamine challenge show high 24 – hour urinary copper excretion.