Comparison of outcomes and safety of concurrent chemoradiotherapy with weekly cisplatin and paclitaxel verses cisplatin alone in locally advanced cervical cancer.

Authors

  • Aalia Bashir Allama Iqbal Teaching Hospital, DG Khan.
  • Anam Siddque Cancer Hospital, Lahore.
  • Muhammad Junaid Hassan NMU Multan.

DOI:

https://doi.org/10.29309/TPMJ/2025.32.10.9988

Keywords:

Chemotherapy, Cisplatin, Radiotherapy, Safety

Abstract

Objective: To evaluate the outcome, survival and safety of weekly combination therapy with cisplatin and paclitaxel chemoradiotherapy in comparison with cisplatin alone in locally advanced cervical cancer. Study Design: Prospective study. Setting: Oncology Department of Nishtar Hospital, Multan. Period: May 2024 to May 2025. Methods: A total of 100 women with locally advanced epithelial cell cervical carcinoma, KPS score of ≥70 and normal bilirubin, urea, creatinine and nitrogen were selected. Patients were divided into control group and study group consisting of 50 patients each. Control group was administered 40 mg/m2 of IV cisplatin once a week with a maximum weekly dose of 70 mg. Study group was administered 50 mg/m2 paclitaxel and 30 mg/m2 cisplatin once a week. External beam radiotherapy was performed in all patients at the same time of chemotherapy targeting cancer site, internal and upper external iliac, uterus, presacral and common iliac lymph nodes. Results: At the last follow-up, 80% patients in control group and 88% in study group survived. 17 patients (34%) in control group and 10 (20%) in study group had a recurrence so the disease-free survival was 66% and 80%, respectively. 12 patients (24%) in control group had local recurrence and 5 (10%) had distant recurrence. 5 patients (10%) in study group had local recurrence and only one (2%) had distant recurrence. No treatment related deaths occurred but 14 patients (28%) in control group and 27 patients (54%) suffered grade 3 or 4 toxicities, the difference was significant (p=0.02). Significantly higher number of patients in study group had gastrointestinal toxicities than control group. Conclusion: Concurrent cisplatin and paclitaxel chemoradiotherapy had better outcomes with increased but manageable toxicities than cisplatin chemoradiotherapy alone.

Author Biographies

Aalia Bashir, Allama Iqbal Teaching Hospital, DG Khan.

FCPS, Senior Registrar Radio Therapy, 

Anam Siddque, Cancer Hospital, Lahore.

FCPS, Radiation Oncology, 

Muhammad Junaid Hassan, NMU Multan.

FCPS, Senior Registrar Radiotherapy, 

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Published

2025-10-02

Issue

Section

Origianl Article