Diagnostic accuracy of Perfusion Computed tomography (PCT) for diagnosis of colorectal carcinoma (CRC) taking histopathology as gold standard.

Abstract

Objective: To determine diagnostic accuracy of Profusion Computed tomography (PCT) for diagnosis of colorectal carcinoma (CRC) taking histopathology as gold standard. Study Design: Descriptive, Cross-sectional. Setting: Department of Radiology, Allied Hospital Faisalabad. Period: 10^th March 2022 to 9^th September 2022. Material & Methods: A total of 451 patients with colorectal cancer suspicion and ages 50-80 years of either gender were included in the study. Patients having severe renal disease, preoperative radiation therapy or chemotherapy, no surgical intervention after CT, contrast media contraindication, pathologically benign colorectal mass, and tumor depth less than 2 cm based on CT were not included. Pre-operative perfusion CTs was performed on all patients. Dynamic perfusion CTs were performed for 65 seconds following intravenous administration of contrast media, and blood flow (BF) and blood volume (BV) in the tumor were assessed. The surgical specimens were forwarded to the hospital's pathology laboratory, where the presence of CRC was labeled according to operational definitions. CT perfusion was performed in radiology department and results of PCT were compared with that of histopathology. Results: Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of Profusion Computed tomography (PCT) in diagnosing colorectal carcinoma (CRC) with histopathology being gold standard was 90.26%, 88.59%, 91.98%, 86.24% and 89.58% respectively. Conclusion: This study concludes that Profusion Computed tomography (PCT) is a highly sensitive and accurate modality for the diagnosis of colorectal carcinoma.