Association of clopidogrel resistance with ethnicity in Pakistan.

Abstract

Objective: The objective of this study was to assess relationship between clopidogrel resistance and different ethnicities in Pakistan. Study Design: Cross-sectional study. Setting: Army Medical College, National University of Medical Sciences (NUMS), Pakistan. Period: 2015 to 2019. Material & Methods: Included 390 ischemic heart disease (IHD) patients on clopidogrel therapy belonging to different ethnicities in Pakistan. Their platelet aggregation was assessed through light transmission aggregometry and the patients were divided into clopidogrel responder and clopidogrel resistant groups. Chi square analysis was done to assess difference in clopidogrel resistance among different ethnicities. One-way ANOVA was applied to assess difference in mean platelet aggregation among different ethnic groups. Results: This study has demonstrated that there was no significant difference in clopidogrel resistance among ischemic heart disease patients belonging to different ethnic groups of Pakistan, p = 0.566. Mean platelet aggregation of all the ethnic groups was also similar, p = 0.330. Conclusion: There is no association of clopidogrel resistance with ethnicity in Pakistan.