Study of Metformin as first line therapy for control of gestational diabetes in Independent University Hospital.

Authors

  • Saadia Bano Independent University Hospital, Faisalabad.
  • Iram Aslam Independent University Hospital, Faisalabad.
  • Saima Qureshi Independent University Hospital, Faisalabad.
  • Uzma Manzoor Independent University Hospital, Faisalabad.
  • Nadia Awais Independent University Hospital, Faisalabad.
  • Tasneem Azhar Independent University Hospital, Faisalabad.

DOI:

https://doi.org/10.29309/TPMJ/2023.30.07.7580

Keywords:

Gestational Diabetes Mellitus, Metformin, Oral Glucose Tolerance Test

Abstract

Objective: To assess the control of gestational diabetes with metformin and to study maternal and fetal outcome in patients using metformin. Study Design: Cross Sectional study. Setting: Department of Obs & Gynae, Independent University Hospital. Period: September 2019 to July 2021. Material & Methods: Eighty six patient diagnosed as having gestational diabetes mellitus by oral glucose tolerance test included in study and Metformin used as first line therapy along with diet for control of blood sugar levels. While patients with insulin dependent diabetes and type 2 DM were excluded from study. Results: It was observed in study, that with metformin use glycemic control was excellent in 70 (81.3%) of patients. Maternal outcome like risk of maternal weight gain>10kg, preeclampsia, and premature births were low in patient usung metformin in pregnancy and as well as neonatal risk of macrosomia, prematurity, neonatal hypoglycemia and need for hospital admission were low with the use of metformin in patients suffering from gestational diabetes. Conclusion: GDM associated adverse outcome for mother like maternal weight gain, pregnancy induced hypertension operative delivery and neonate like macrosomia, birth trauma, neonatal hypoglycemia are well controlled by the use of life style modification and metformin use in almost >80 % of cases only in few cases there is additional need of insulin therapy. Maternal and fetal outcome found to be satisfactory with the use of metformin. Further studies are required to build a more confidence.

Author Biographies

Saadia Bano, Independent University Hospital, Faisalabad.

MBBS FCPS, Associate Professor Obst & Gynae, 

Iram Aslam, Independent University Hospital, Faisalabad.

MBBS FCPS, Associate Professor Obst & Gynae, 

Saima Qureshi, Independent University Hospital, Faisalabad.

MBBS FCPS, Professor Obst & Gynae, 

Uzma Manzoor, Independent University Hospital, Faisalabad.

MBBS FCPS, Associate Professor Obst & Gynae, 

Nadia Awais, Independent University Hospital, Faisalabad.

MBBS FCPS, Associate Professor Obst & Gynae, 

Tasneem Azhar, Independent University Hospital, Faisalabad.

MBBS FCPS, Associate Professor Obst & Gynae, 

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Published

2023-07-02