A comparison of Lipid Profile and Highly Sensitive C Reactive Protein (HsCRP) levels between prehypertensive individuals and those with normal blood pressure.

Abstract

Objective: In the current study, hsCRP and lipid profile levels in prehypertensives were assessed and compared with those in normal subjects, as well as blood pressure and lipid profile correlations were examined. Study Design: Cross-sectional. Setting: Department of Physiology, Liaquat University of Medical & Health Sciences (LUMHS) in Jamshoro. Period: Six months 1^st November 2022 to 30^th April 2023. Material & Methods: From the general population, 50 pre-hypertensive and 50 normotensive subjects ranging in age from 25 to 55 were enrolled. A blood pressure measurement and an anthropometric measurement were taken. Student t tests were used to compare serum hsCRP with lipid profiles. In order to correlate blood pressure with hsCRP and lipid profile, Pearson correlation was used. Results: A significant correlation was not found between blood pressure (SBP and DBP) and hsCRP in either group. When compared to normal individuals, pre-hypertensives had significantly higher cholesterol and LDL (P-value <0.001). Among prehypertensive patients, blood pressure and lipid parameters did not seem to be significantly correlated. Conclusions: We conclude that in both prehypertensive and normal subjects, hsCRP levels are not significantly different. Therefore, pre-hypertensive patients do not have inflammation. Prehypertensive patients have significantly higher total cholesterol and LDL levels than normal individuals. There is an alteration in the lipid profile of prehypertensive individuals.