Impact of fermented lactobacilli acidophilus and antibiotics topically during the phase of re-epithelization in wound repair of rats.

Abstract

Objective: To compare the topical effects of lactobacillus acidophilus strain and topical antibiotics during the phase of re-epithelization in wound repair. Study Design: Experimental Longitudinal study. Setting: Al-Tibri Medical College, Isra University Karachi. Period: June to November 2022. Material & Methods: This longitudinal study took place in in which 45 Wistar rats were acquired and divided into three groups, Group A the control group in which normal saline was applied, Group B in which topical Lactobacillus acidophilus was applied, and Group C in which topical neomycin was applied on the 3^rd, 7^th, and 14^th day of the study. A subcutaneous incision was given on all the rats of equal proportion, and on the 3^rd, 7^th, and 14^th day of sampling a histological section was acquired. A micrometer was used to measure the thickness of the dermis and epidermis. Data was analyzed using SPSS, with the p-value set at <0.05. Results: Significant difference was seen in the mean thickness of epidermis when Lactobacillus acidophilus groups was compared with both Group A and C on the 3^rd, 7^th, and 14^th day of the study. Significant difference was also seen in the mean thickness of the dermis when Lactobacillus acidophilus was compared with both Group A and C on the 3^rd, 7^th, and 14^th day of the study. Conclusion: Lactobacillus acidophilus plays a potent rote in repairing dermal tissue as it increased the thickness of dermis and epidermis.