Anti hyperlipidemic effect of Oxyresveratrol and Zinc complex versus simvastatin on Total Cholesterol in Hyperlipidemic rat Model.

Authors

  • Aqsa Tazarrat Mohi-ud-din Islamic Medical College.
  • Farhana Ayub Poonch Medical College Rawlakot.
  • Bushra Rehman Foundation University.
  • Wajahat Ullah Khan Mohi-ud-din Islamic Medical College.
  • Salma Salim Mohi-ud-din Islamic Medical College.
  • Sidra Ashfaq Rawal Institute of Health Sciences.

DOI:

https://doi.org/10.29309/TPMJ/2022.29.06.6879

Keywords:

Atherosclerosis, High Fat Diet, Oxyresveratrol, Simvastatin, Total Cholesterol

Abstract

Objective: To determine the Anti hyperlipidemic effect of Oxyresveratrol and Zinc complex on Total Cholesterol in Hyperlipidemic rat Model. Study Design: Experimental study. Setting: Islamic International Medical College Rawalpindi. Period: Sep 2020 to Sep 2021. Material & Methods: In our study on high fat diet fed hyperlipidemic rats comparison of this standard drug with a novel compound oxyresveratrol was done. Forty rats were randomly divided into 4 groups, Group I was used as NC (Negative Control), group II Positive Control (PC), group III (OXY-Zn complex) and group IV SIM respectively. Groups III and IV were given orally 10 mg/kg body wt. OXY-Zn and SIM respectively. Terminal sampling was performed on day 57 for estimation of total cholesterol. Results: OXY-Zn complex showed significantly better control over total cholesterol compared with SIM. Total cholesterol of OXY treated group showed p < 0.001 like SIM treated group (p < 0.001). Conclusion: Our results showed that OXY-Zn complex is better than simvastatin because of its significantly positive effect on total cholesterol when compared with SIM.

Author Biographies

Aqsa Tazarrat, Mohi-ud-din Islamic Medical College.

MBBS, M.Phil, Demonstrator Biochemistry, 

Farhana Ayub, Poonch Medical College Rawlakot.

MBBS, M.Phil, PhD, CHPE, Professor, 

Bushra Rehman, Foundation University.

MBBS, M.Phil, Demonstrator, 

Wajahat Ullah Khan, Mohi-ud-din Islamic Medical College.

MBBS, M.Phil, CHPE, Assistant Professor Biochemistry, 

Salma Salim, Mohi-ud-din Islamic Medical College.

MBBS, M.Phil, Demostrator Pharmacology, 

Sidra Ashfaq, Rawal Institute of Health Sciences.

MBBS, M.Phil, Senior Lecturer Biochemistry, 

Downloads

Published

2022-05-31