Correlation of serological markers and thombocytopenia in Dengue infection - a cross sectional study from 2019 epidemic in Rawalpindi, Pakistan.

Authors

  • Javaria Malik District Head Quarter Hospital Rawalpindi Medical University Rawalpindi, Pakistan.
  • Maha Batool District Head Quarter Hospital Rawalpindi Medical University Rawalpindi, Pakistan.
  • Tahira Yasmeen District Head Quarter Hospital Rawalpindi Medical University Rawalpindi, Pakistan.
  • Shehzad Manzoor District Head Quarter Hospital Rawalpindi Medical University Rawalpindi, Pakistan.
  • Hamza Waqar Bhatti Benazir Bhutto Hospital Rawalpindi Medical University Rawalpindi, Pakistan.
  • Shumaila Mumtaz District Head Quarter Hospital Rawalpindi Medical University Rawalpindi, Pakistan.

DOI:

https://doi.org/10.29309/TPMJ/2022.29.06.6342

Keywords:

Dengue Serological Marker, NS1 antigen, Platelet Count, Thrombocytopenia

Abstract

ABSTRACT… Objective: To recognize the spectrum of serological markers found in dengue cases and to associate them with the platelet count. Study Design: Cross Sectional Study. Setting: Department of Medicine, District Head Quarter Hospital, and Rawalpindi, Pakistan. Period: August to November 2019. Material & Methods: Serum was analyzed to detect markers of NS1 antigen, IgM and IgG using the ELSIA technique. The platelet count was likewise noted in all of the samples. Data was analyzed by SPSS v25.0. Results: 226 patients with dengue fever were enrolled in the study samples. Among 226 examples 63(27.9%) were positive for isolated NS1 antigen and 10 (4.4%) were positive for isolated IgM. Out of 134 positive primary infection cases, 108(80.5%) had thrombocytopenia while out of 92 secondary infection cases, 74(80.4%) had thromobocyte count ˂100,000/mm3. Overall, thrombocytopenia was recorded in 182(80.5%) out of 226 dengue positive cases. Conclusion: In the present research work, the relationship of low platelet count in dengue-parameters positive cases was seen as exceptionally critical. The thrombocyte count, in addition to dengue-specific parameters, is the main available diagnostic test in less developed areas that may be used to confirm the diagnosis of dengue infection.

Author Biographies

Javaria Malik, District Head Quarter Hospital Rawalpindi Medical University Rawalpindi, Pakistan.

MBBS, FCPS, Senior Registrar Medicine, 

Maha Batool, District Head Quarter Hospital Rawalpindi Medical University Rawalpindi, Pakistan.

MBBS, House Officer Medicine, 

Tahira Yasmeen, District Head Quarter Hospital Rawalpindi Medical University Rawalpindi, Pakistan.

MBBS, FCPS, Senior Registrar Medicine, 

Shehzad Manzoor, District Head Quarter Hospital Rawalpindi Medical University Rawalpindi, Pakistan.

MBBS, FCPS, Head of Department Medicine, 

Hamza Waqar Bhatti, Benazir Bhutto Hospital Rawalpindi Medical University Rawalpindi, Pakistan.

MBBS, House Officer Medicine, 

Shumaila Mumtaz, District Head Quarter Hospital Rawalpindi Medical University Rawalpindi, Pakistan.

MBBS, FCPS, Senior Registrar Medicine, 

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Published

2022-05-31