Paracetamol induced liver enzyme (AST/ALT) changes in dengue fever.

Authors

  • Kiran Hafeez Isra University Hospital. Hyderabad, Sindh, Pakistan.
  • Muhammad Akbar Memon Isra University Hospital Hyderabad, Sindh, Pakistan.
  • Zia Farooqui Isra University Hospital Hyderabad, Sindh, Pakistan.
  • Haseeb Jameel Memon Civil Hospital, Hyderabad.
  • Kamran Baig Memon Isra University Hospital Hyderabad, Sindh, Pakistan.
  • Abdul Aziz Isra University Hospital Hyderabad.

DOI:

https://doi.org/10.29309/TPMJ/2022.29.06.6103

Keywords:

Dengue Fever, Liver Damage, Pakistan

Abstract

Objective: To determine the Paracetamol induced liver enzyme (AST/ALT) changes in dengue fever in a tertiary care hospital of Hyderabad. Study Design: Observational Study. Setting: Emergency Department of Medicine, Isra University Hospital, Hyderabad. Period: May 2018 to May 2019. Material & Methods: A total of 100 patients of age ≥12 years with dengue fever were included. AST and ALT levels were obtained in the first week and third week of course of illness. Paracetamol was used for anti-pyretic/analgesia purpose was compared of first week with third week. Statistical analysis was done using SPSS. Chi-square test and student’s t-test were applied as appropriate. P value ≤0.05 was considered as significant. Results: Out of total 100 patients, there were 56% males and 44% females and overall mean age was 35.21±15.13 years. The overall mean weight, height, BMI, and mean duration of fever in days was 61.13±17.26 kg, 1.60±0.14 meter, 23.85±6.73 kg/m2, and 4.20±1.43 days, respectively. Independent t test shows significant mean difference of AST/ALT ratio at 1st week (p=0.000) as well as at 3rd week (p=0.020) according to paracetamol dose. Conclusion: In our study, results showed significant improvement in AST, ALT, and AST/ALT ratio at 1st week and 3rd week.

Author Biographies

Kiran Hafeez, Isra University Hospital. Hyderabad, Sindh, Pakistan.

MBBS, FCPS (Medicine), Assistant Professor Medicine, 

Muhammad Akbar Memon, Isra University Hospital Hyderabad, Sindh, Pakistan.

MBBS, FCPS (Medicine), Associate Professor Medicine, 

Zia Farooqui, Isra University Hospital Hyderabad, Sindh, Pakistan.

MBBS, MRCP, Senior Registrar Medicine, 

Haseeb Jameel Memon, Civil Hospital, Hyderabad.

MBBS, Resident, 

Kamran Baig Memon, Isra University Hospital Hyderabad, Sindh, Pakistan.

MBBS, MD (Internal Medicine) Senior Registrar Medicine, 

Abdul Aziz, Isra University Hospital Hyderabad.

MBBS, MRCP, Medical Welfare Ward, 

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Published

2022-05-31