Comparison of efficacy of metformin in obese versus non-obese women of PCOS presenting with menstrual irregularities.

Abstract

Objective: To compare the efficacy of metformin in obese and non-obese women with polycystic ovarian disease presenting with menstrual irregularities. Study Design: Quasi Experimental study. Setting: Department of Gynecology and Obstetrics, Sargodha Medical College at Maula Bukhsh Teaching Hospital under Dr Fasal Masood Teaching Hospital Sargodha. Period: July 2022 to August 2023. Methods: Total 156 patients (78 in each group) were selected based on predefined inclusion and exclusion criteria. Patients were randomized in 2 groups according to their BMI. Group A consists of obese women while Group B had non obese women according to predefined operational definition. All patients were given tablet metformin 500mg twice a day and followed up for total of 06 months at every 03 month interval consecutively. On each visit patients were asked about their menstrual cycle regarding duration of bleeding days and length of menstrual cycle. Data entry was done by SPSS version 26. Independent sample t-test was applied to compare mean of numeric data between both groups. A p< 0.05 was considered statistically significant. Results: Result showed that metformin was significantly more effective in non-obese women as compared to obese women i-e obese 34.62% vs non obese 50% p value 0.051. Conclusion: Results of this study showed that metformin is more effective in treating non obese patients as compared to obese patients in terms of menstrual irregularities.