Effect of different manipulations on serum PSA in patients with benign prostatic hyperplasia.

  • Muhammad Iqbal University College of Medicine and Dentistry, Lahore.
  • M. Adil Khurshid CMH Medical College Lahore.
  • Sohail Hassan Sahara Medical College, Narowal.
  • Manzoor Ahmad Naeem UCMD, Lahore.
  • Shahid Niaz Sahara Medical College, Narowal.
  • Ammad Ahmad Siddiqui Sahara Medical College, Narowal.
Keywords: Benign Prostatic Hyperplasia, Carcinoma Prostate, Prostatic Specific Antigen, Prostatic Needle Biopsy, TURP

Abstract

Objectives: To evaluate the effect of different urological manipulations on the serum PSA level in patients with benign prostatic hyperplasia. Study Design: Quasi-experimental study. Setting: Department of Urology, Nawaz Sharif Social Security Hospital, Lahore. Period: January 2018 to December 2018. Material & Methods: A series of 60 patients were included in the study who fulfill the inclusion criteria. All the patients were above 50 years of age and presented with symptoms of benign prostatic hyperplasia. These patients were divided into four groups equally. In group A digital rectal examination, in group B transurethral resection of prostate, in group C Foley’s catheterization and in group D Trans rectal ultrasound guided prostatic biopsy was done. Pre-manipulation and post-manipulation blood samples for serum PSA were taken after 30 minutes, 72 hours and one week. Results: Trans urethral resection of prostate, Foley's catheterization and trans rectal ultrasound guided prostatic biopsy caused a statistically significant rise in serum PSA level (p < 0.05) while digital rectal examination did not raise serum PSA level significantly. Conclusion: Different manipulations do cause alteration in the serum PSA level which may change the management plan.

Author Biographies

Muhammad Iqbal, University College of Medicine and Dentistry, Lahore.

MBBS, MS (Urology)

Senior Registrar Urology

 

M. Adil Khurshid, CMH Medical College Lahore.

MBBS, MS (Urology)

Associate Professor Urology

Sohail Hassan, Sahara Medical College, Narowal.

MBBS, MS (Urology)

Associate Professor Urology

Manzoor Ahmad Naeem, UCMD, Lahore.

MBBS, Ph.D (Nephrology)

Associate Professor Nephrology

Shahid Niaz, Sahara Medical College, Narowal.

MBBS, M.Phil (Biochemistry)

Senior Lecturer Biochemistry

Ammad Ahmad Siddiqui, Sahara Medical College, Narowal.

MBBS, MS (Urology)

Senior Registrar Urology

Published
2021-06-10