Recurrence rate of superficial bladder cancer with intravesical BCG and mitomycin.

  • Khalid Hussain Gujranwala Medical College, Gujranwala.
  • Muhammad Asif Islam Medical College and Teaching Hospital Gujranwala
  • Farooq Malik Sir Ganga Ram Hospital, Lahore.
  • Munazza Yasmeen Aviccena Medical College, Lahore.
  • Maria Tariq Gujranwala Medical College, Gujranwala.
  • Attiq-ur-Rehman Khan DHQ Teaching Hospital Gujranwala/ Gujranwala Medical College, Gujranwala.
Keywords: Intravesical BCG, Mitomycin-C, Superficial Transitional Cell Carcinoma of Urinary Bladder

Abstract

Objective: To compare the recurrence rate of superficial transitional cell carcinoma of urinary bladder using intravesical BCG and Mitomycin-C. Study Design: Randomized Controlled Trial. Setting: Urology Department, Teaching DHQ Hospital, Gujranwala. Period: November 2018, to Sep, 2019. Material & Methods: Was carried out on total 270 patients, admitted with suspicion of urothelial tumors. They were grouped in Group A and B, comprising 135 in each group. Group A received BCG and Group B received Mtiomycin-C intravesically following TUR-BT. Results: Out of 270 patients male to female ratio was 3:1. Age range of patients was between 30 to 70 years with mean of 50.0± 13.1 and 552.3 ± 12.9 years in Group A and B respectively. Recurrence was noted in 05.38% and 15.38% patients in Group A and B respectively. Regarding side effects pyrexia was associated with BCG in 27.40% patients which were self-limited in 26.66% cases however required anti-tuberculosis therapy for six months in 0.74%. Whereas only 06.67% patients receiving Mitomycin had pyrexia. Dysuria occurred in 74% and frequency in 68% patients who received BCG. Whereas Dysuria occurred in 20% and frequency in 36.29% patients who received Mitomycin-C. However genital skin rash was more common (08.14%) in Mitomycin group than BCG. Conclusion: Keeping in mind less recurrence rate and bearable toxicity, it is concluded that BCG is superior to Mitomycin. This study suggests long term follow up is required to establish recurrence in the management of superficial bladder cancer.

Author Biographies

Khalid Hussain, Gujranwala Medical College, Gujranwala.

MBBS, MS (Urology)

Professor Urology

Muhammad Asif, Islam Medical College and Teaching Hospital Gujranwala

MBBS, MS (Urology)

Assistant Professor Urology

 

Farooq Malik, Sir Ganga Ram Hospital, Lahore.

MBBS, MS (Urology)

Senior Registrar Urology

Munazza Yasmeen, Aviccena Medical College, Lahore.

MBBS, M.Phil (Pathology)

Assistant Professor Pathology

 

Maria Tariq, Gujranwala Medical College, Gujranwala.

MBBS

Post graduate Resident Urology

 

Attiq-ur-Rehman Khan, DHQ Teaching Hospital Gujranwala/ Gujranwala Medical College, Gujranwala.

MBBS, MS (Urology)

Assistant Professor Urology

 

Published
2021-06-10